What Ten-Year Persistence of CD19 CAR-T in Lymphoma Means
A study published in Nature Medicine followed 38 patients with B-cell non-Hodgkin lymphoma treated with 4-1BB-costimulated CD19 CAR-T for up to ten years. The results showed that C...
Immunology and Cell Therapy
Missing Helios: Why Do Regulatory T Cells Go Out of Control?
In autoimmune research, regulatory T cells (Tregs) are generally regarded as the "brakes" that suppress excessive immune responses. However, a mouse study published in the Journal ...
SHP1 Deficiency: A Newly Discovered Inflammatory Lung Disease and Hemolytic Anemia in Children
Research Background Severe inflammatory lung disease, including acute respiratory distress syndrome (ARDS), has a high mortality rate and limited targeted therapeutic options. Rece...
High-Risk Smoldering Myeloma: Can Bispecific Antibodies Move Forward to Early Intervention
In the randomized phase II ImmunoPRISM trial, patients with high-risk smoldering multiple myeloma received a fixed course of the BCMA×CD3 bispecific antibody teclistamab, achieving...
Why HIV Rebounds Later After Dual-Antibody Treatment Is Stopped
A phase 2 randomized trial shows that in people who started antiviral treatment early, two long-acting broadly neutralizing antibodies can delay viral rebound during an analytical ...
The "Key Switch" of Tumor Immunity: An Overlooked Class of Activated Dendritic Cells
Tumor immunotherapy does not always work, and one often-overlooked reason lies at the starting point of the immune response. Dendritic cells (DCs) are responsible for presenting tu...
The "Courier" Hidden in B Cells: How SorLA Affects the Immune Response
After infection and vaccination, whether the body can produce highly effective antibodies depends on whether B cells can "capture" antigens and present them to T cells. This proces...
CD137 Deficiency Accelerates Autoimmune Diabetes: The Key Defense Line of Regulatory T Cells
The onset of autoimmune diseases arises from the immune system mistakenly attacking the body's own tissues. Regulatory T cells (Tregs) are the core cell population that maintains i...
Can Bispecific Antibodies Clear EBV-Associated Lymphoma More Thoroughly?
More than 90% of adults carry Epstein-Barr virus (EBV) for life, yet rarely develop disease. But EBV is classified by the World Health Organization as a Group I carcinogen, associa...
Can Cutaneous T-Cell Lymphoma Be Differentiated Without Biopsy? Tape-Stripping Transcriptomics Offers a New Answer
Early diagnosis of cutaneous T-cell lymphoma (CTCL) has long been a challenge for dermatologists. This is especially true for the most common type, mycosis fungoides (MF), whose ea...