Anti-Exatecan (Exatecan mesylate) monoclonal antibody (mAb)
Anti-Exatecan (Exatecan Mesylate) monoclonal antibody (mAb)
Anti-Exatecan monoclonal antibody (mAb) for ADC is designed and developed for selective cancer therapy, targeting Exatecan Mesylate, a topoisomerase I inhibitor.
Exatecan binds and inhibits topoisomerase I involved in DNA replication, leading to cancer cell death without affecting other cells.
View the application of Exatecan Mesylate (Exatecan) in ADC
Download MSDS
Order Information
| Catalog No. | Product Name | Specification | Inquiry |
|---|---|---|---|
| GTU-Bios-Eribulin-Ab-1 | Anti-Exatecan (Exatecan Mesylate) humanized monoclonal antibody (mAb) | 1mg | |
| GTU-Bios-Eribulin-Ab-2 | Anti-Exatecan (Exatecan Mesylate) mouse monoclonal antibody (mAb) | 1mg | |
| GTU-Bios-Eribulin-Ab-3 | Anti-Exatecan (Exatecan Mesylate) mouse monoclonal antibody (mAb) | 1mg | |
| GTU-Bios-Eribulin-Ab-1 | Anti-Exatecan (Exatecan Mesylate) humanized monoclonal antibody (mAb) | 100μg | |
| GTU-Bios-Eribulin-Ab-2 | Anti-Exatecan (Exatecan Mesylate) mouse monoclonal antibody (mAb) | 100μg | |
| GTU-Bios-Eribulin-Ab-3 | Anti-Exatecan (Exatecan Mesylate) mouse monoclonal antibody (mAb) | 100μg |
(Available sizes: 1mg | 10mg | 100mg)
Description
Anti-Exatecan (Exatecan Mesylate) Human Monoclonal Antibody (Human mAb)
Catalog Number (Cat No.)
GTU-Bios-Eribulin-Ab-1
Product Name (Product Name)
Anti-Exatecan (Exatecan Mesylate) Human Monoclonal Antibody
Target (Target)
Exatecan Mesylate (Eribulin Mesylate)
Expression platform (Expression platform)
Mammalian cell
Isotypes (Isotypes)
Human IgG1
Bioactivity validation
Exatecan Mesylate binding assay;
Validated by competitive immunoassay in Exatecan level testing (competitive ELISA).
Validated by competitive immunoassay in Exatecan level testing (competitive ELISA).
Tag
hFc
Products description
Anti-Exatecan Mesylate monoclonal antibody, expressed by mammalian cells.
Species
Human
Purity
≥95% (SDS-PAGE)
Application (Application)
Competitive immunoassay verification (Competitive ELISA) and other immunoassays;
PK & PD analysis of Exatecan payload in antibody-drug conjugates (ADC).
PK & PD analysis of Exatecan payload in antibody-drug conjugates (ADC).
Formulation & Reconstitution
Lyophilized from GM Protein Stabilization Buffer 2 (PSB2, proprietary) or PBS (pH7.4);
PSB2 reconstitute with 0.9% sodium chloride;
Reconstitute PBS with deionized water (ddH2O).
PSB2 reconstitute with 0.9% sodium chloride;
Reconstitute PBS with deionized water (ddH2O).
Storage Conditions (Storage)
Store under sterile conditions at -20°C to -80°C. Avoid repeated freeze-thaw cycles.
Anti-Exatecan (Exatecan Mesylate) Mouse Monoclonal Antibody (Mouse mAb)
Catalog Number (Cat No.)
GTU-Bios-Eribulin-Ab-2, GTU-Bios-Eribulin-Ab-3
Product Name (Product Name)
Anti-Exatecan (Exatecan Mesylate) Mouse Monoclonal Antibody
Target (Target)
Exatecan Mesylate (Eribulin Mesylate)
Expression platform (Expression platform)
Mammalian cell
Isotypes (Isotypes)
Mouse IgG (Mouse IgG)
Bioactivity validation
Exatecan Mesylate binding assay;
Validated by competitive immunoassay in Exatecan level testing (competitive ELISA).
Validated by competitive immunoassay in Exatecan level testing (competitive ELISA).
Tag
mFc
Products description
Anti-Exatecan Mesylate (Exatecan Mesylate) Mouse Monoclonal Antibody, expressed in mammalian cells.
Species
Mouse
Purity
≥95% (SDS-PAGE)
Application (Application)
Competitive immunoassay verification (Competitive ELISA) and other immunoassays;
PK & PD analysis of Exatecan payload in antibody-drug conjugates (ADC).
PK & PD analysis of Exatecan payload in antibody-drug conjugates (ADC).
Formulation & Reconstitution
Lyophilized from GM Protein Stabilization Buffer 2 (PSB2, proprietary) or PBS (pH7.4);
PSB2 reconstitute with 0.9% sodium chloride;
Reconstitute PBS with deionized water (ddH2O).
PSB2 reconstitute with 0.9% sodium chloride;
Reconstitute PBS with deionized water (ddH2O).
Storage Conditions (Storage)
Store under sterile conditions at -20°C to -80°C. Avoid repeated freeze-thaw cycles.
Validation Data (Validation Data)
GeneMedi Anti-Exatecan Antibody Demonstrates High Specificity
Illustration: GeneMedi's GTU-Bios-Exatecan-Ab: Specifically binds Exatecan, does not bind SN38.
A. Exatecan ADC binding activity assay results show that GTU-Bios-Exatecan-Ab-2 (EC50 = 0.06271 nM) and GTU-Bios-Exatecan-Ab-3 (EC50 = 0.07254 nM) have strong binding affinity to Exatecan ADC.
B. In SN38 ADC binding assay, GTU-Bios-Exatecan-Ab-2 and GTU-Bios-Exatecan-Ab-3 showed no binding (N.A.), demonstrating high specificity.
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