Anti-methotrexate (MTX) monoclonal antibody (mAb)
ianti-MTX-monoclonal-antibody
Theoretically, an anti-methotrexate monoclonal antibody (mAb) antibody-drug conjugate (ADC) with methotrexate (MTX) would bind to cells containing the chemotherapeutic drug MTX, as MTX inhibits dihydrofolate reductase. This enables targeted delivery of MTX, thereby enhancing its ability to inhibit cell growth and division, particularly in cancer cells, while reducing systemic toxicity.
However, this approach falls under later research and is not a formal application of current ADC technology.
Please refer to the application of methotrexate (MTX) in ADCs.
MSDS
Order Information
| Catalog No. | Product Name | Specification |
|---|---|---|
| GTU-Bios-MTX-Ab-1 | Anti-methotrexate (MTX) human monoclonal antibody (mAb) | 1mg |
| GTU-Bios-MTX-Ab-2 | Anti-MTX (methotrexate) mouse monoclonal antibody (mAb) | 1mg |
| GTU-Bios-MTX-Ab-3 | Anti-MTX (methotrexate) mouse monoclonal antibody (mAb) | 1mg |
Size： 1mg | 10mg | 100mg
Description
Anti-methotrexate (MTX) human monoclonal antibody (mAb)
Catalog No.
GTU-Bios-MTX-Ab-1
Product Name
Anti-methotrexate (MTX) human monoclonal antibody (mAb)
Target
Methotrexate (MTX)
Expression Platform
Mammalian cell
Isotype
Human IgG1
Biological Activity Verification
Methotrexate (MTX) conjugation, competitive immunoassay validation (competitive ELISA) application in detection of methotrexate (MTX) levels.
Tag
hFc
Product Description
Anti-methotrexate (MTX) monoclonal antibody expressed by mammalian cells.
Species Source
Human
Purity
Purity: ≥95% (SDS-PAGE)
Application
Competitive immunoassay validation (competitive ELISA) for MTX payload in antibody-drug conjugates (ADCs) and other immunoassays, PK and PD assays.
Formulation and Reconstitution
Lyophilized from GM's Protein Stabilization Buffer 2 (PSB2, confidential composition) or PBS (pH7.4);
For PSB2, reconstitute with 0.9% sodium chloride;
For PSB2, reconstitute with 0.9% sodium chloride;
For PSB2, reconstitute with 0.9% sodium chloride;
For PSB2, reconstitute with 0.9% sodium chloride;
Storage Conditions
Store under sterile conditions at -20°C to -80°C. Avoid repeated freeze-thaw cycles.
Anti-MTX (methotrexate) mouse monoclonal antibody (mAb)
Catalog No.
GTU-Bios-MTX-Ab-2, GTU-Bios-MTX-Ab-3
Product Name
Anti-MTX (methotrexate) mouse monoclonal antibody (mAb)
Target
Budesonide
Expression Platform
Mammalian cell
Isotype
Mouse IgG
Biological Activity Verification
Methotrexate (MTX) conjugation, competitive immunoassay validation (competitive ELISA) application in detection of methotrexate (MTX) levels.
Tag
mFc
Product Description
Anti-Methotrexate (MTX) mouse monoclonal antibody (mAb) expressed in mammalian cells.
Species Source
Mouse
Purity
Purity: ≥95% (SDS-PAGE)
Application
Competitive immunoassay validation (competitive ELISA) for MTX payload in antibody-drug conjugates (ADCs) and other immunoassays, PK and PD assays.
Formulation and Reconstitution
Lyophilized from GM Protein Stabilization Buffer 2 (PSB2, proprietary) or PBS (pH7.4);
PSB2 reconstitute with 0.9% sodium chloride;
PBS reconstitute with ddH2O.
PSB2 reconstitute with 0.9% sodium chloride;
PBS reconstitute with ddH2O.
Storage Conditions
Store under sterile conditions at -20°C to -80°C. Avoid repeated freeze-thaw cycles.
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